Mr. King-Parkinson Syndrome-(Canada)

Name: Mr. King
Sex: Male
Nationality: Canada
Age: 71Y
Diagnosis: 1. Parkinson Syndrome 2. Diabetes type2                     
Discharge Date: 2019/02/07

Before treatment:
Six years ago the patient had stiffness in the left leg, he also had inflexibility and slowness of movement. He went to the local hospital and was diagnosed with "Parkinson's Disease". He was treated with drugs such as " Sinemet and Resagilan" and his condition was improved but there were still fluctuations in the slow movement of the limbs. One year ago he had a decline of limb balance and ataxia, he got up and walked slowly and in an unstable way but he was still able to take care of himself.
His diet is good, he sleeps bad at night, he has poor control of urination, polyuria at night, constipation and his weight loss is 15kg. He has had type 2 diabetes for many years but his blood sugar is well controlled.

Admission PE:
Bp: 150/88mmHg, Hr: 76/min, breathing rate: 19/min. The patient displayed a slightly unstable gait. Nutrition status is good with normal physical development. There is no injury or bleeding spots of his skin and mucosa, no blausucht, no throat congestion, and his tonsils do not have swelling. The respiratory sounds in both lungs were clear and there were no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and no obvious murmur in the valves. The abdomen was flat and soft, with no masses or tenderness. The liver and spleen were normal and there is no edema of the legs.

Nervous System Examination:
Patient was alert, had a mild slur and fast speech. His memory,  comprehension and calculation abilities were normal . Both pupils were equal in size and round, diameter of 2.5 mm, the reaction to light was sensitive, his eyeballs can move freely and there was no nystagmus. The bilateral forehead wrinkle and nasolabial fold are symmetrical, he could not blink in a flexible way, he could make his tongue extend out normally, there was mild tongue muscle tremor and the tongue could move flexibly. The soft palate could lift powerfully, the uvula was normal and he could turn his neck powerfully. There was slightly slow movement of the 4 limbs, he had static tremor occasionally and the hands wax-waning sign were positive, especially on the left side. The arms muscle power was 5 degrees, the legs were 4- degrees, he could roll over in bed, get up or walk slowly. There is no obvious movement starting difficulties when he walks and the 4 limbs muscle tone were basically normal. The bilateral biceps reflex, triceps reflex and radial periosteal reflex existed, bilateral patellar tendon reflex and Achilles tendon reflex were lower than normal, the Hoffmann sign and Rossilimo sign of both sides were negative, sucking reflex and palm-jaw reflex were negative. Right side Babinski sign was neutral, left side was positive. His sensory system examinations were normal, his finger opposite movement, fast alternate movement and finger to nose test were clumsy, especially the left side. Heel-knee-tibia test was not stable, left side was much more severe and there was a mild positive of his Romberg sign. He could not walk straight or stand with one leg. The meningeal irritation sign was negative.

After the admission he received 3 nerve regeneration treatments (neural stem cells and mesenchymal stem cells) to repair his damaged nerves, replace dead nerves, nourish nerves (ganglioside, nerve growth factors and neurotrophic factors), improve body environment, regulate his immune system and improve blood circulation. This was combined with rehabilitation training.   

After 13 days treatment his static tremor was gone, his slow movement relieved, the coordinate movement ability improved, he could turn over his body easier and walk with a much more stable gait. The patient could now stand in a much more stable way with his eyes closed and he could stand with one leg for 10 seconds. The night urination frequency reduced and he now urinated 1-2 times each night and he slept better.

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