Krishnan Nair Padmanbhan-Parkinson Disease-(India)

Name: Krishnan Nair Padmanbhan
Sex: Male
Nationality: Indian
Age: 67Y
Diagnosis: Parkinson Disease
Discharge Date: 2018/11/26

Before treatment:
The patient developed limb and lumbar back muscle pain 4 years ago and was diagnosed with lumbar radiculopathy and bilateral median nerve compression neuropathy. After that there was static tremor of the right limbs, especially in the right arm, which was characterized by ball-like involuntary movement. In August 2018 it was clearly diagnosed as "Parkinson's Disease" and he was treated with oral anti-Parkinson's drugs (Praxol 0.5mg three times a day). At present the patient can take care of himself completely, the right limb still has tremor and the tremor is more obvious in the morning.
His diet and weight are normal, he needs pills for sleeping, his urination and defecation function are normal. 

Admission PE:
Bp 119/70mmHg, Hr: 64/min, breathing rate: 19/min, height 172cm, weight 91.5Kg. Nutrition status is good. There is no injury or bleeding spots of his skin and mucosa, no blausucht, no throat congestion and his tonsils do not have swelling. The respiratory sounds in both lungs were clear and there were no dry or moist rales. The heart beat is powerful with regular cardiac rhythm, distant heart sounds and no obvious murmur in the valves. The abdomen was soft with no masses or tenderness. The liver and spleen were normal and there is no edema of the legs.

Nervous System Examination:
Patient was alert, had clear speech, his memory was decreased. The comprehension and calculation ability were normal. He had a natural facial expression, both pupils were equal in size and round, diameter of 3.0 mm and the reaction to light was sensitive. His eyeballs can move freely, there was no nystagmus. The bilateral forehead wrinkle and nasolabial fold are symmetrical, he could make his tongue extend out normally, there was no tongue muscle tremor and the tongue muscle could move flexibly. The soft palate could lift powerfully, the uvula was normal, his neck was soft and he could turn his head powerfully There was involuntary tremor of his right body side, obvious pill-rolling tremor of his right arm, the 4 limbs muscle power was 5 degrees with normal muscle tone of the 4 limbs. The abdomen reflex, bilateral biceps reflex, triceps reflex, the radial periosteal reflex, patellar tendon reflex and Achilles tendon reflex could not be induced. The Hoffmann sign and Rossilimo sign of both sides were negative, sucking reflex was negative, bilateral palm-jaw reflex was positive, the Babinski sign was a strengthened positive. The sensory system was normal, his right side finger to nose test and finger opposite movement were not very stable, the fast alternate movement of both sides were clumsy, especially the right side. The heel-knee-tibia test was normal, the Romberg sign of both sides were negative, the meningeal irritation sign was negative.

Treatment:
After the admission he received 3 nerve regeneration treatments (neural stem cells and mesenchymal stem cells) to repair his damaged nerves, replace dead nerves, nourish nerves (ganglioside, nerve growth factors and neurotrophic factors), improve the body environment, regulate his immune system and improve blood circulation. This was combined with rehabilitation training.   

Post-treatment:
After 12 days treatment his pain in the back and limbs was significantly reduced, his right body side tremor reduced, the coordinate movement and fast alternate movement of both sides were much flexible than before and the balance control was much better also.